Aryna Sabalenka enters the French Open Round of 16 as the world number one and strong favourite at 1.21 decimal odds. The Belarusian has shown mixed recent form on clay, recording wins against Jacquemot, Bouzas Maneiro and Krejcikova, though she suffered losses to Cirstea and Baptiste in her last five matches. Sabalenka holds a 1–0 head-to-head record against Osaka and will look to extend that advantage on the demanding clay surface.

Naomi Osaka, ranked 16th, faces an uphill battle against Sabalenka at 4.92 decimal odds in this French Open Round of 16 encounter. The Japanese player has shown promising recent form with four wins in her last five matches, including victories over Vekic, Siegemund and Shnaider, though she fell to world number one Iga Swiatek in straight sets. Osaka's career record against Sabalenka stands at 0–1, meaning she will be seeking her first victory against the Belarusian on the Roland Garros clay.