Casper Ruud enters the French Open first round as the 16th-ranked player from Norway, holding a 1–0 head-to-head record against Holger Rune's recent opponent. His recent form shows mixed results on clay, with four wins in his last five matches including victories over Brooksby, Popyrin, and Collignon, though he suffered a straight-set loss to Mariano Navone. The world number 16 will aim to convert his clay-court consistency into a strong opening performance at Roland Garros.

Holger Medjedovic arrives as the 58th-ranked player from Serbia seeking an upset against the higher-seeded Ruud in the opening round. The Serbian player has won three of his last five matches, including recent victories over Navone, Fonseca, and Royer, though he suffered a straight-set defeat to Landaluce. Medjedovic's form demonstrates competitive ability on clay, and he will need to sustain momentum to challenge Ruud's tournament experience at the French Open.