Burruchaga enters the Cagliari quarterfinals as the higher-ranked player at world number 59, looking to build momentum after a recent run of three consecutive victories over Walton, Nakashima, and Tien. The Argentine's clay-court form has been solid, though he suffered a straight-set loss to Taylor Paul in his most recent match. With the head-to-head record tied 1–1 against Pellegrino, Burruchaga will aim to control the baseline and capitalize on his ranking advantage in this quarterfinal encounter.

Pellegrino, ranked 130th and representing Italy, arrives in Cagliari with inconsistent recent form marked by three losses in his last five matches, including straight-set defeats to Damm and Sachko. The Italian did secure a two-set win over Sakellaridis and a straight-set victory over Jianu in his recent run, showing he can find rhythm on clay. Pellegrino's even 1–1 head-to-head record against Burruchaga suggests competitive history, though he faces an uphill battle against the Argentine's higher ranking in this quarterfinal matchup.