Dalibor Prizmic arrives at Madrid as the 87th-ranked player from Croatia, carrying momentum from three consecutive wins over Matteo Berrettini, Zoran Piros, and Christopher O'Connell on clay. The Croatian has shown solid form in recent weeks, though he suffered a straight-sets loss to Raphael Collignon in his most recent outing. This marks Prizmic's first meeting with Tomás Martín Etcheverry, offering no head-to-head history between the pair on the ATP tour.

Tomás Martín Etcheverry enters the Madrid 1/16-finals as Argentina's highest-ranked player in this matchup at world number 29, bringing a mixed clay-court record into the round. The Argentine has alternated results recently, combining wins over Grigor Dimitrov and Sebastien Ofner with losses to Nuno Borges and Carlos Alcaraz in his last five matches. Etcheverry and Prizmic have never faced each other competitively, setting up an intriguing first encounter on the Spanish clay.